Annulating Ambiphile Mapping Paper – Now In Press

The final peer-reviewed version of our collaborative paper with Pfizer mapping reactivity trends in the Pd(II)/Pd(IV) catalytic annulation of alkenyl amides appears online today in Angewandte Chemie International Edition. In the paper, we describe protocols for synthesizing a diverse array 5-, 6-, and 7-membered carbon/heterocycles of ambiphilic organohalides and show how changing the structure of the nucleophile and electrophile influences reactivity. Congrats to Hui-Qi, Philliipaa, and Pranali from the Scripps Research and Shouliang, Fen, Neal, Joyann, Michelle, and Indra from Pfizer Oncology Medicinal Chemistry for another great collaboration!

Click here for a link to the article in Angewandte Chemie International Edition:

As a reminder, a pre-print of the paper first appeared in ChemRxiv back in October: