Conjunctive Cross-Coupling with Allyl Groups – Pre-print Online

In a pre-print appearing online today in ChemRxiv, Van, Zi-Qi, Tim, and Joe describe the first successful integration of allyl electrophiles into nickel-catalyzed conjunctive cross-coupling. Key to the success of this reaction is use of a series of weakly coordinating heterocycle directing groups that allow the alkene moiety of the allyl group to coordinate and promote challenging C(sp3)–C(sp3) reductive elimination, as supported by computational studies in collaboration with the Liu group at the University of Pittsburgh. Click here for a link to the paper.

Fourth Annual Beach Day!

The Engle Lab took a break from lab work to celebrate the arrival of three new graduate students, the successful PhD defense by Zhen, and everyone’s hard work over the past year. We stuck to tradition and grilled food, played volleyball, and relaxed!

Zhen defends his PhD!

Today, we celebrated Zhen passing his thesis defense with flying colors! It’s been a honor to work with him these past few years and we will be forever grateful for the leadership he showed this lab! He will soon be off to post-doc with Professor Frances Arnold at Caltech!

Nhi, Matt and Kane Present at the Summer Intern Poster Session!

Rock star high school interns; Nhi, Matt, and Kane, presented posters on their summer internships at the Scripps Research Summer Intern Poster Session! When asked what they learned from the internship, the overwhelming answer from these three amazing junior scientists was “basic lab skills and the ability to persevere in the face of failure”. We couldn’t be prouder to help these incredible students start their careers! We’re excited to see what they do next!

Welcome First Year Graduate Students!


We are super excited to welcome first year graduate students Aaron, Huiqi, and Omar to the Engle lab!

Aaron hails from Florida and worked in polymer chemistry while completing his BS at Florida State. After graduation he interned at BMS discovery before making it to the West Coast just in time for orientation!

Huiqi is a familiar face around here as she completed an 8-week internship with us while she worked on her BS at University of Science at Technology of China! She is no stranger to organometallic catalysis!

Omar is also a former undergraduate student! He completed his undergraduate work at CSUSM and did a SURF internship with us his junior year. After graduation he interned at Johnson and Johnson and has his eyes on #teamnickel!

We are so incredibly lucky to have such amazing people join our lab!

Tanner Advances to Candidacy!

Congrats to rising G3 student Tanner Jankins for successfully passing his qualifying exam and advancing to candidacy! We are super excited to see what new methodology (and metals!) Tanner will develop in our lab – stay tuned for some awesome chemistry coming to a journal near you!


2019 Organometallics Bootcamp Kicks Off This Week

For the second year running, senior members of the Engle lab are organizing an Organometallics Bootcamp for incoming first-year grad students and visiting undergraduates in the Chemistry Department at Scripps Research. The 10-day bootcamp typically meets mornings from 9–10 AM along with some evenings, and it covers topics ranging from basic structure and bonding to state of the art cross-coupling methods. Bootcamp kicks off Wednesday morning at 8:30 am in the Library Training Room (404H). Please email if you are interested in participating.