Conjunctive Cross-Coupling with Allyl Groups – Pre-print Online

In a pre-print appearing online today in ChemRxiv, Van, Zi-Qi, Tim, and Joe describe the first successful integration of allyl electrophiles into nickel-catalyzed conjunctive cross-coupling. Key to the success of this reaction is use of a series of weakly coordinating heterocycle directing groups that allow the alkene moiety of the allyl group to coordinate and promote challenging C(sp3)–C(sp3) reductive elimination, as supported by computational studies in collaboration with the Liu group at the University of Pittsburgh. Click here for a link to the paper.