Our latest collaboration with Pfizer, Inc. and the Liu group at the University of Pittsburgh describing the copper-catalyzed hydroboration of benzylidenecyclobutanes (BCBs) and related four-membered ring compounds has been accepted for publication in ACS Catalysis. Key to the success of this method was the identification of a modified 1,2-bis(diphenylphosphino)benzene (dppbz) ligand that enhances reactivity through π-stacking interactions with the substrate, as elucidated by density functional theory (DFT). Congrats to Taeho and Kane from our lab, Tuğçe from the Liu lab at Pittsburgh, and Gary, Alex, Sajiv, Ryan, Ru, Scott, and Indra from Pfizer. Special props to high-school senior Kane for co-authoring his second paper!
For a link to the paper, click here: https://pubs.acs.org/doi/10.1021/acscatal.0c03622
This work was first described back in August: https://chemrxiv.org/articles/preprint/Multifaceted_Substrate_Ligand_Interactions_Promote_the_Copper-Catalyzed_Hydroboration_of_Benzylidenecyclobutanes_and_Related_Compounds/12788390