Continuing with our recent theme of developing new methods for C(sp3)–S bond formation via nickel-catalyzed syn-carbosulfenyation of alkenes, in today’s ChemRxiv pre-print we describe a new three-component method for combining alkylzinc nucleophiles, sulfur electrophiles, and unactivated alkenes. The method complements previous methodology from our group by expanding the scope of C(sp2) nucleophiles to C(sp3) nucleophiles and is enabled by use a bidentate directing auxiliary group. The method is compatible with a diverse collection of coupling partners including various E– and Z-configured internal alkenes. Congrats to the project team, grad students Zi-Qi and Hui-Qi and visiting undergrad Wen-Ji. Great work team!
For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/6233b0c08ab3732b56687bad