The final version of our paper describing the directed 1,2-oxyhalogenation of unactivated alkynes appears online today in Angewandte Chemie International Edition. In this investigation, we demonstrate the successful extension of our labs approach for modular three-component π-bond functionalization from alkenes to alkynes. Specifically, we find that the 2-(pyridin-2-yl)isopropyl (PIP) amine directing auxiliary is able to mediated the classically challenging regioselective, three-component oxyhalogenation of internal alkynes, allowing for simple preparation of tetrasubstituted alkenes containing diversifiable functional handles. Congrats to Mingyu, Juntao, and Raul from Scripps, as well as our collaborators from the Lan group and Zhengzhou University and the Shi Lab at Zhejiang University.

For a link to the peer-reviewed paper in Angew. Chem. Int. Ed., click here: https://onlinelibrary.wiley.com/doi/10.1002/anie.202209099

For the initial pre-print that was deposited at the end of June, click here: https://chemrxiv.org/engage/chemrxiv/article-details/62a263752e62696e467d88b5

It has been a long time since we’ve been able to enjoy a group outing! This week, we did just that. We headed downtown to Petco stadium for an awesome Padres home game! It was great welcoming our new class of students and bringing back some old traditions!