Alkyne 1,2-Oxyhalogenation In Press at Angewandte Chemie

The final version of our paper describing the directed 1,2-oxyhalogenation of unactivated alkynes appears online today in Angewandte Chemie International Edition. In this investigation, we demonstrate the successful extension of our labs approach for modular three-component π-bond functionalization from alkenes to alkynes. Specifically, we find that the 2-(pyridin-2-yl)isopropyl (PIP) amine directing auxiliary is able to mediated the classically challenging regioselective, three-component oxyhalogenation of internal alkynes, allowing for simple preparation of tetrasubstituted alkenes containing diversifiable functional handles. Congrats to Mingyu, Juntao, and Raul from Scripps, as well as our collaborators from the Lan group and Zhengzhou University and the Shi Lab at Zhejiang University.

For a link to the peer-reviewed paper in Angew. Chem. Int. Ed., click here:

For the initial pre-print that was deposited at the end of June, click here: