Traditional syntheses of low-valent nickel complexes, such as the archetypal Ni(0) species, Ni(COD)2, require the use stoichiometric quantities of pyrophoric organometallic reductants, such as DIBAL–H, which pose operational and safety complications. In our most recent study, we report a convenient, green, and scalable electroreductive route to Ni(COD)2 as well as other useful low-valent nickel species, including the air-stable Ni(0) precatalyst, Ni(COD)(DQ), that avoids stoichiometric reductants altogether. The method can conveniently performed using the standardized IKA ElectraSyn 2.0 or alternatively in a recirculating flow setup. Congrats to the entire collaborative team: Camille (Engle lab, Scripps Research & Vantourout lab, University of Lyon; Yilin (Engle lab, Scripps Research), Tamara and Gabriele (Baran lab, Scripps Research); Greg and Steve (Bristol Myers Squibb); and Xiangyu (Lin lab, Cornell).
For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/642b6699a029a26b4cde3e3e