N-Alkylation of 2-Pyridones with Alkenes

In a manuscript appearing online today in Tetrahedron, John, Van, and Miranda report a new method to effect intermolecular N-alkylation of 2-pyridones using an alkene as the alkylating reagent. The reaction employs a directed nucleopalladation/protodepalladation strategy and functions with a range of 2-pyridones and related aza-heterocycles. Special congratulations to our undergraduate co-author, Miranda, who also just completed her undergraduate degree at UCSD! The manuscript is part of a special issue celebrating Prof. Ang Li’s 2017 Tetrahedron Young Investigator Award. Click here for a link to the manuscript. Way to go, team!

TOC_web

IMG_2549(not pictured: Miranda)

Controlled Hydrochlorination of Alkynes with HCl

In the Engle lab’s first paper of 2017, the team of Joe, Annabelle, Mark, Miriam, Josh, Zhen, and Daizy describe a new catalytic method to effect regio- and stereoselective addition of HCl to alkynes using a directed nucleopalladation strategy. The paper appears today in the Just Accepted section of J. Am. Chem. Soc. Well done, everyone! Special congrats to the three undergraduate co-authors, Annabelle, Mark, and Josh, as well as Daizy, the Engle lab’s first-ever high school student co-author! Click here for a link to the paper.

hydrochlorination
IMG_2378(not pictured: Annabelle, Josh, and Daizy)

Forrest finishes his internship

The Engle lab bids farewell to Zichen (Forrest) Wang, who has completed his 6-month internship. After an inspiring and productive stay at Scripps, Forrest returns to Nankai University equipped with a group of lifelong friends, new chemistry knowledge, a refined appreciation for hamburgers, and improved laser tag skills.

Lab Tours + Demos with Partners in Science

For the second straight year, the Engle lab hosted a group of high school teachers from across the United States through the MJ Murdock Charitable Trust – Partners in Science Program. The Partners in Science Program provides opportunities for high school teachers to work with investigators in academic labs or in labs associated with other non-profit institutions to bring the knowledge and experience back to classroom, promoting hands-on science education. Members of the Engle lab explained our group’s research, organized a series of hands-on activities, and even coaxed a few brave teachers into the glovebox.

Sri joins as the Engle lab’s newest postdoc

The Engle lab is pleased to usher in 2017 by welcoming its newest postdoc, Sri Krishna Nimmagadda. Sri originally hails from Chirala, India, and completed his Ph.D. with Jon C. Antilla at the University of South Florida, where his research focused on the catalytic asymmetric synthesis using chiral phosphoric acids and alkaline earth metal phosphate complexes.