Zhen defends his PhD!

Today, we celebrated Zhen passing his thesis defense with flying colors! It’s been a honor to work with him these past few years and we will be forever grateful for the leadership he showed this lab! He will soon be off to post-doc with Professor Frances Arnold at Caltech!

Nhi, Matt and Kane Present at the Summer Intern Poster Session!

Rock star high school interns; Nhi, Matt, and Kane, presented posters on their summer internships at the Scripps Research Summer Intern Poster Session! When asked what they learned from the internship, the overwhelming answer from these three amazing junior scientists was “basic lab skills and the ability to persevere in the face of failure”. We couldn’t be prouder to help these incredible students start their careers! We’re excited to see what they do next!

Welcome First Year Graduate Students!


We are super excited to welcome first year graduate students Aaron, Huiqi, and Omar to the Engle lab!

Aaron hails from Florida and worked in polymer chemistry while completing his BS at Florida State. After graduation he interned at BMS discovery before making it to the West Coast just in time for orientation!

Huiqi is a familiar face around here as she completed an 8-week internship with us while she worked on her BS at University of Science at Technology of China! She is no stranger to organometallic catalysis!

Omar is also a former undergraduate student! He completed his undergraduate work at CSUSM and did a SURF internship with us his junior year. After graduation he interned at Johnson and Johnson and has his eyes on #teamnickel!

We are so incredibly lucky to have such amazing people join our lab!

2019 Organometallics Bootcamp Kicks Off This Week

For the second year running, senior members of the Engle lab are organizing an Organometallics Bootcamp for incoming first-year grad students and visiting undergraduates in the Chemistry Department at Scripps Research. The 10-day bootcamp typically meets mornings from 9–10 AM along with some evenings, and it covers topics ranging from basic structure and bonding to state of the art cross-coupling methods. Bootcamp kicks off Wednesday morning at 8:30 am in the Library Training Room (404H). Please email keary@scripps.edu if you are interested in participating.

2019 *NSPIRE Symposium

*NSPIRE, an organization co-founded by Keary in 2018, held its inaugural Symposium (#NSPIRE2019) at the McMahan House on the campus of CSU San Marcos. #NSPIRE2019 brought together roughly 80 students and faculty from all four partner institutions (Scripps Research, CSU-SM, MiraCosta, and Palomar) for a series of talks by the the 2019 *NSPIRE Fellows, a poster session, and info sessions about research and educational opportunities at Scripps Research. All participants braved the sweltering heat for lively discussion and active networking. Thank goodness for AC inside during the talks! Keep your eyes out for more to come from *NSPIRE.

About *NSPIRE: The North County San Diego Professional and Interdisciplinary Research Enrichment (*NSPIRE) program (www.nspireinitiative.com) is a partnership between Scripps Research, CSU San Marcos, Palomar, and MiraCosta that operates with financial support of the North County Higher Education Alliance (NCHEA3). The

syn-selective 1,2-carboboration and -silylation pre-print online

Our latest work on directed alkene functionalization appears online today as a preprint in ChemRxiv. Specifically we describe a method for Pd(0)-catalyzed alkene syn-1,2-carboboration and -silylation, allowing streightforward access to structural complex alkylboronates and -silanes. Notable aspects of the method include its tolerance for all different alkene substitution patterns (mono-, di-, tri-, and tetrasubstituted alkenes), with the regioselectivity completely dictated by the directing group. Additionally, electron-rich heterocycles, such as indole, can also participate in this reaction; undergoing dearomative 1,2-difunctionalization. We further show that a chiral bidentate directing group can be used in place of the standard 8-aminoquinoline auxiliary to allow for control of absolute and relative stereochemistry in the reactions. Congrats to all of the coauthors from the Engle lab: Zhen, Jiahao, Xiaohan, and Yang (particularly undergrad co-authors Jiahao and Xiaohan). Thanks too to our BMS collaborators and organoboron grand masters, Ryan and Matt. Well done, team! (For a link to the article, click here.)