In a ChemRxiv pre-print appearing today, we present the development of Pd(COD)(DQ), a highly stable Pd(0) source that can be used in organometallic synthesis and catalysis. We describe an operationally simple synthesis that can be performed on decagram scale; demonstrate ligand exchange with numerous phosphine, nitrogen, and NHC ligands; and showcase a variety of catalytic carbon–carbon and carbon–heteroatom coupling reactions. Pd(COD)(DQ) offers numerous benefits compared to the most widely used Pd(0) source, Pd2(dba)3, that we anticipate will make it a valuable addition to the synthetic toolkit. Congrats to the collaborative team from Scripps Research, UCSD, and Bristol Myers Squibb!
Check out the pre-print here: https://chemrxiv.org/engage/chemrxiv/article-details/65e8f798e9ebbb4db918a09f
Molecular Complexity through Catalysis 