The Engle lab celebrates its third lab-iversary at Scripps. Thanks to all coworkers for another awesome year of science and many fun memories! Here’s to another great year ahead.
Appearing online today in J. Am. Chem. Soc., the Engle lab and Cravatt group report the results of a joint investigation, encompassing the discovery of a new copper-catalyzed method to access branched alkenyl nitriles from simple alkenes and exciting applications of these compounds in organic synthesis and chemical proteomics. Congrats to all coauthors: De-Wei, Sri, Jose, and Yiyang (Elaine) from the Engle lab; and Katya and Radu from the Cravatt lab. Thanks to the Cravatt lab for a great collaboration (hopefully, the first of many). Click here for a link to the article.
Congratulations to Keary and the entire Engle lab for receiving the prestigious 2018 American Chemical Society (ACS) Petroleum Research Fund (PRF) Doctoral New Investigator Award. The grant will support research efforts focused on developing synthetically useful oxidative alkene functionalization reactions with copper. Nice job!
Appearing online today is a new manuscript from a collaboration between the Engle lab and Bristol-Myers Squibb (BMS) describing the directed aminohydroxylation of non-conjugated alkenes using a weak oxidation system (2,6-dimethylbenzoquinone and O2 in HFIP). This method represents a convenient means of accessing beta-hydroxy-gamma-amino acids in an expedient manner from simple starting materials. To interrogate the reaction mechanism, we teamed up with process chemistry phenoms Drs. Mike Schmidt and Martin Eastgate from BMS, and together we established that the OH group of the product originates from O2 (potentially through the intermediacy of a peroxide or other reactive oxygen species). Congratulations to Tian (May) and Zhen from the Engle group as well as BMS coauthors Mike and Martin. Special props to undergraduate first author Tian (May), who managed to get the paper accepted only a few days before packing up and heading to her summer internship at Genentech, where she will spend a few months before starting her PhD at Caltech. May was the first undergraduate to publish a paper in the Engle group in 2016 and fittingly becomes the first undergraduate to complete a first-author contribution. Way to go team, and thanks to BMS for a great collaboration!
We are excited to have a new TSRI SURF student Omar joining us this summer. Omar is working under guidance of Mingyu (G2) and is already in the hood trying out some new methods for making non-conjugated acids. Omar is looking forward to learning about catalysis and trying out some new Chinese restaurants in San Diego.
In order to celebrate the graduation of two outstanding undergraduate students, May and Vincent, we held our second group scavenger hunt, with each team tasked with finding locations and items around the TSRI campus and taking photos in entertaining poses. After completing the scavenger hunt, we had a quick round of dodgeball, before capping the day off with games and drinks at Brewskis Bar & Arcade. Thanks to May for organizing a great day, and congratulations to May and Vincent on all of their accomplishments! For a slideshow of the event, click below. For photos of the setup and party see further below or check out #EngleHunt on twitter.
Visiting graduate student Xin joins the lab this week. She is doing her graduate studies in medicinal chemistry and will be doing a year long visit in the Engle Lab. Xin is looking forward to enjoying the southern California summer learning more about catalysis.