Appearing online today is a new manuscript from a collaboration between the Engle lab and Bristol-Myers Squibb (BMS) describing the directed aminohydroxylation of non-conjugated alkenes using a weak oxidation system (2,6-dimethylbenzoquinone and O2 in HFIP). This method represents a convenient means of accessing beta-hydroxy-gamma-amino acids in an expedient manner from simple starting materials. To interrogate the reaction mechanism, we teamed up with process chemistry phenoms Drs. Mike Schmidt and Martin Eastgate from BMS, and together we established that the OH group of the product originates from O2 (potentially through the intermediacy of a peroxide or other reactive oxygen species). Congratulations to Tian (May) and Zhen from the Engle group as well as BMS coauthors Mike and Martin. Special props to undergraduate first author Tian (May), who managed to get the paper accepted only a few days before packing up and heading to her summer internship at Genentech, where she will spend a few months before starting her PhD at Caltech. May was the first undergraduate to publish a paper in the Engle group in 2016 and fittingly becomes the first undergraduate to complete a first-author contribution. Way to go team, and thanks to BMS for a great collaboration!
We are excited to have a new TSRI SURF student Omar joining us this summer. Omar is working under guidance of Mingyu (G2) and is already in the hood trying out some new methods for making non-conjugated acids. Omar is looking forward to learning about catalysis and trying out some new Chinese restaurants in San Diego.
In order to celebrate the graduation of two outstanding undergraduate students, May and Vincent, we held our second group scavenger hunt, with each team tasked with finding locations and items around the TSRI campus and taking photos in entertaining poses. After completing the scavenger hunt, we had a quick round of dodgeball, before capping the day off with games and drinks at Brewskis Bar & Arcade. Thanks to May for organizing a great day, and congratulations to May and Vincent on all of their accomplishments! For a slideshow of the event, click below. For photos of the setup and party see further below or check out #EngleHunt on twitter.
Visiting graduate student Xin joins the lab this week. She is doing her graduate studies in medicinal chemistry and will be doing a year long visit in the Engle Lab. Xin is looking forward to enjoying the southern California summer learning more about catalysis.
Huge congratulations to the Class of 2018! The Engle lab is incredibly proud of our recent college and high school graduates, who are moving on to incredible graduate and undergraduate programs around the world!
Vincent van der Puyl (UCSD): The Scripps Research Institute (Ph.D. in Chemistry)
Yiyang (Elaine) Xiao (Nankai U): Peking U (Ph.D. in Chemistry)
Pusu Yang (Nankai U): SIOC (Ph.D. in Chemistry)
Tian (May) Zeng (UCSD): Caltech (Ph.D. in Chemistry)
High School Student
Forrest Graham (Valhalla High School): Caltech
Tim Gallagher joins The Engle Lab (mentor Van) for as summer research intern where he hopes to hone in his organometallics knowledge and enjoy the beautiful beaches of southern California. Tim is originally from northern Vermont where he enjoys skiing and snowboarding and will be a 4th year student at Claremont Mckenna College this fall (Wenzel Lab).