Free-Amine-Directed 1,2-Carboamination of Alkenes – Now In Press

The final version of our paper on free-amine-directed 1,2-carboamination of alkenes under nickel catalysis is available online today in ACS Catalysis. In this manuscript, we describe how careful tuning of the reactivity of the nitrogen electrophile through modification of the leaving group allows for the first example of three-component 1,2-difunctionalization of alkene with a free amine directing group. The reaction proceeds with a broad scope of organoboron coupling partners, cyclic and acyclic amine electrophiles, and primary and secondary alkenyl amine substrates. Congrats to Taeho, José, and Zi-Qi, as well as our collaborators Klement and Peter from discovery chemistry at Bristol Myers Squibb.

For a link to the paper, click here:

As a reminder, a pre-print of the paper first appeared in ChemRxiv back in December 2021: