The final version of our redox-paired alkene difunctionalization paper appears online today in J. Am. Chem. Soc. In this study, we outline a novel redox paradigm for alkene difunctionalization in which an oxidative difunctionalization process is coupled to a reductive difunctionalization process without any additional terminal oxidants or reductants. The unique mechanism of this reaction involves a PdII/PdIV/PdII/PdIV catalytic cycle, as elucidated through experiment and computations. Congrats to the entire project team, and thanks to our collaborators Prof. Ken Houk from UCLA and Prof. Peng Liu from the University of Pittsburgh.
For a link to the paper in J. Am. Chem. Soc., click here: https://pubs.acs.org/doi/10.1021/jacs.3c03274.
As a reminder, a pre-print of this work was deposited at the end of 2022: https://chemrxiv.org/engage/chemrxiv/article-details/63ad635fff4651a6983afddf
Molecular Complexity through Catalysis 