Today we are pleased to announce publication of a collaborative study with Prof. Yu Lan’s group at Zhengzhou University elucidating the mechanism of nickel-catalyzed conjunctive cross-coupling reactions of alkenes, aryl iodides, and organozinc reagents, which reveals a previously under-appreciated role of the organozinc reagent as a Z-type ligand that facilitates reductive elimination. This revised mechanistic model explains how this type of conjunctive cross-coupling can proceed under such mild conditions without specialized ligand, despite involving a typically challenging C(sp3)–C(sp3) reductive elimination event. Congrats to the entire project team!
For a link to the paper in J. Am. Chem. Soc., click here: https://pubs.acs.org/doi/full/10.1021/jacs.2c09739
Molecular Complexity through Catalysis 