Tandem Isomerization/Carbonylation Enabled by Low-Valent Tungsten Redox Catalysis – Paper In Press with Nature Chemistry

The final version of our study on site-selective W(0)/W(II)-catalyzed alkene isomerization/carbonylation appears this week in Nature Chemistry. In this method, we take advantage of the ability of tungsten to undergo changes between six- and seven-coordinate geometries during the W(0)/W(II) redox couple. In conjunction with a conformationally flexible bidentate directing auxiliary, selective isomerization to (and subsequent functionalization at) classically disfavored positions can be achieved. Congrats to project lead Tanner and visiting undergrad Ziyang (Nick); our collaborators at the University of Pittsburgh, Will, Yu, and Peng; our resident analytical wizard Jason from the Scripps ASF, and crystallographer extraordinaire Milan from UCSD.

For a link to the final version of the paper in Nature Chemistry, click here: https://www.nature.com/articles/s41557-022-00951-y

As a reminder, a pre-print of the paper was deposited in ChemRxiv back in April 2021: https://chemrxiv.org/engage/chemrxiv/article-details/60c757089abda23076f8e61a