The final, peer-reviewed version of our study in collaboration with the process chemistry team at Boehringer-Ingelheim on alkyne cross-coupling to access 1,3-enynes appears this week in J. Am. Chem. Soc. The high regio- and stereoselectivity of this reaction stems from the use of a hindered P,N-ligand previously developed at BI, which Mingyu and the BI team identified during his summer internship in Ridgefield, CT. Hats off to the entire project team: Mingyu, Tianhua (Josh), Omar, and Rei from Scripps Research; and Carl, Bo, Dan, Olga, Chris, and Jinhua (Jeff) from BI. Not a bad way to follow up your successful thesis defense from last week, Dr. Liu!
For a link to the paper, click here: https://pubs.acs.org/doi/10.1021/jacs.0c12565
This work first appeared as a pre-print back in October: https://chemrxiv.org/articles/preprint/Atom-Economical_Cross-Coupling_of_Internal_and_Terminal_Alkynes_to_Access_1_3-Enynes/13083419