directed cyclization pre-print online

Appearing today as a pre-print in ChemRxiv we describe a series of Pd(II)-catalyzed intramolecular alkene hydrofunctionalization reactions, where we take advantage of a proximal directing group to recruit the metal catalyst and promote otherwise disfavored rings closures. This work was part of a fun collaboration with the Liu group at the University of Pittsburgh and the Xiang group at Nankai University Medical School. Congrats to the three project leads: Xin (a visiting PhD student from Nankai University who spent one year in our lab in La Jolla, Zi-Qi (a second-year PhD student at Scripps Research), and Binh (a postdoc at the University of Pittsburgh). Props to the rest of the team, especially former high-school intern Jessica Xu, who carried out critical proof-of-concept studies in the summer of 2016 and is now an undergraduate student at MIT. Way to go, team!

For a link to the pre-print, click here: https://chemrxiv.org/articles/Controlling_Cyclization_Pathways_in_Palladium_II_-Catalyzed_Intramolecular_Alkene_Hydrofunctionalization_via_Substrate_Directivity/12090402