The latest work from our collaboration with Bristol-Myers Squibb was recently accepted for publication in Angewandte Chemie International Edition. This manuscript described the developments of new methods for Pd(0)-catalyzed alkene 1,2-carboboration and -silylation. Compared to prior art, these methods are much more effective with internal alkenes (including tri- and tetrasubstitued). We even show examples of dearomative 1,2-carboboration of electron-rich heterocycles. Lastly, we identified a chiral directing group that enables control of the absolute configuration of the final products. Congrats to all Engle lab coauthors, Zhen, Hou-Xiang, Jiahao, Xiaohan, and Yang, especially our three undergrad co-authors, Hou-Xiang, Jiaohao, and Xiaohan (now in the Ph.D. program at UCSB). It was awesome teaming up with BMS again for this project — thanks to Ryan and Matt for an awesome collaboration!

For a link to the paper, click here: https://onlinelibrary.wiley.com/doi/10.1002/anie.201910304