Umpolung Carboamination Preprint Online

The first of three birthday preprints is now online at ChemRxiv. The manuscript describes our adventures in using N–O electrophiles in nickel-catalyzed alkene functionalization, namely directed 1,2-carboamination of alkenyl carbonyl compounds. This work represents the first example of a three-component nickel-catalyzed reaction employing an N–O reagent. In terms of preparative utility, the transformation enables controlled formation of highly hindered C–N bonds, offering a potentially powerful platform for applications in medicinal chemistry. Congrats to the authors, Vincent (who performed the lion’s share of the work as his undergraduate project) and Joe (who was a great mentor throughout the process). Well done! For a link to the manuscript, click here.