Three-component alkene carboamination

In a manuscript appearing online today in J. Am. Chem. Soc., Zhen, Zichen (Forrest), and Tian (May) have teamed up with computational collaborators Yanyan Wang and Prof. Peng Liu at the University of Pittsburg to describe a new method to effect three-component carboamination of unactivated alkenes. The article describes reaction optimization, substrate scope, synthetic applications toward several drug compounds, reaction kinetics, and computational studies. This works marks the first collaboration with another research group from the Engle lab—hopefully the first of many! Special congratulations to undergraduate co-authors, Forrest and May. Forrest recently completed his undergraduate degree at Nankai University and will be joining the PhD program at the Shanghai Institute of Organic Chemistry. Click here for a link to the manuscript. Great work, team!


(not pictured: Zichen (Forrest))