Engle Lab Receives NIH Support

The Engle lab is thrilled to announce that we have received our first NIH grant, the Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (R35). We are honored to received support from the NIH and hope to put it to good use for the advancement of science.

For a write-up in TSRI News and Views, click here.
For a link to the funding announcement, click here.

Engle Lab Beach BBQ

The Engle lab took time away from lab to enjoy some time on the beach to celebrate Forrest’s completion of his internship and to welcome Pusu and Elaine to the group. Even though the skies were grey, we were not deterred. We grilled a lot of good food, relaxed in the sand, played volleyball and soccer, and wrapped up the night up with a game of Werewolf. Awesome way to wind down the summer!

Original NMR Files Now Available in Publications

As of last week, the Engle lab has begun publishing original NMR spectra (as MNova zip files)  with all papers. Our goal is make it easier for end-users to adopt new reactions from our laboratory and to promote the highest possible levels of transparency in chemical research.  Check out the Supporting Information pages for our recent alkene dicarbofunctionalization and carboamination reactions for more details. Spectrometer files (FIDs) are also available upon request.

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Hydroamination Review is Online

John’s new review article, “Regioselective Hydroamination Using a Directed Nucleopalladation/Protodepalladation Approach,” is online as of this morning at Synlett. The article covers the historical context for our group’s work in this area, published results from our laboratory, as well as outlook and perspective. Thanks to the Editorial Board at Synlett for the awesome opportunity to contribute this Synpact article, and congrats to John on a well-written piece! Click here for a link to the paper.

hydroamination review

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Tanner Arrives and Begins Research in the Engle Lab

After a diverse set of research experiences at GlaxoSmithKline, Novartis, University of Tsukuba (J. Ichikawa), and the Okinawa Institute of Science and Technology (J. Khusnutdinova), Tanner Jankins begins graduate school at TSRI in the Engle lab. A graduate of Northeastern University, Tanner wasted no time jumping into the lab to begin preparing new ligand scaffolds, while still finding time to hit the beach for some surfing.

Pusu begins his research internship

Fresh off of the plane from Beijing, Pusu Yang arrives for a six-month research internship in the Engle Lab at Scripps. Pusu is a senior undergraduate at Nankai University, and at NKU he carries out research on rare-earth metal catalysts in the laboratory of Prof. Bingtao Guan. Having grown up in inner-Mongolia, Pusu is happy to swap the summer heat of Tianjin for the temperate climate of San Diego.

Ni-catalyzed conjuctive cross-coupling with unactivated alkenes

Today marks the Engle lab’s first foray into nickel catalysis. Congratulations to Joe, Van, and Mark for their paper in J. Am. Chem. Soc., which describes a new method to couple alkylzinc reagents, aryl iodides, and non-conjugated alkenes using a coordination control strategy. The work couldn’t have happened with our collaborator Jason Chen, the Director of the brand-new TSRI Automation Facility, who guided us through several challenging purifications and analyses. Special congratulations to Mark, who caps off his recent graduation from UCSD with the second paper of his undergraduate career. Click here for the link to the paper. Way to go, team!

Ni Cross-Coupling_TOC

IMG_2947(Not pictured: Mark)