After a fantastic six weeks, we bid farewell to our high school intern Mayia Wagner, who heads back home to complete her senior year at Montrose High School in Colorado. In the Engle lab, Maiya developed new synthetic methods for accessing materials and medicines. Thanks to the Pinhead Institute for supporting this internship program and to Madison for great mentorship throughout the summer!

For a link to Maiya’s blog tracker her summer experience, click here: https://www.pinheadinstitute.org/category/intern-blogs/2025-interns/maiya-wagner/

This week marked the last days for two awesome colleagues, Evan Morgan and Alejandro (Alex) Suárez Lustres, who have spent the last few months in the Engle lab. Evan wraps us his postbac stay and will move to the Bay Area to take up a position as a medicinal chemist at Gilead. Alex will return to his home institution, University of Santiago de Compostela (Spain), where he will wrap up his Ph.D. with Profs. Carlos Saá and Jesús Varela over the course of the next year. We celebrated their time in the lab with food and festivities. Thanks to both Evan and Alex for making crucial scientific contributions and for being great colleagues!

This week the Engle lab celebrated 10 incredible years at Scripps Research with a surprise party, including a video montage, cake, and everyone’s favorite food—Hawaiian BBQ! Looking forward to several more decades ahead of research, teaching, and mentorship!

In our latest work, we describe a dual catalytic double Mizoroki–Heck arylation of ortho-(2-propenyl)benzaldehydes to furnish a special class of styrenyl products exhibiting equivalent atrop- and positional isomerism. The molecules are unique; inversion about the hindered C(aryl)–C(alkenyl) bond is equivalent to relocating the olefin to adjacent position (i.e., transposing a single H atom). Congrats to the entire collaborative team: Amit, Yiyao, Wen-Ji, and Madeline from Scripps Research; and Turki from the Liu lab at the University of Pittsburgh.

For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/6835b62d1a8f9bdab53f41a4

Congrats to Wen-Ji and Al, whose article on “Duroquinone” in the Encyclopedia of Reagents for Organic Synthesis, appears online this week. The article summarizes synthetic approaches to this molecule, its reactivity profile, and applications in organic synthesis and coordination chemistry. Well done, team!

For a link to the article in e-EROS, click here: https://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn02611

A while back we observed formation of an unexpected byproduct in an attempted screen of various ketone-based transient directing groups (TDGs) for metal-catalyzed difunctionalization of ortho-alkenylaniline substrates. After initial condensation to form the corresponding ketimine, cyclization took place to furnish the corresponding dihydro-1-benzazepines. Recognizing the utility of the products, we optimized high-yielding reaction conditions, explored the scope and limitations of the method, and evaluated the potential of the products as ligands for transition metals. We are pleased to share the culmination of these efforts this week in Tetrahedron Letters as part of a special issue celebrating Prof. Song Lin’s Tetrahedron Young Investigator Award. Hats off to Alena and Jose for invaluable preliminary data and Letian and Juntao for getting the project to the finish line.

For a link to the paper in Tetrahedron Letters, click here: https://www.sciencedirect.com/science/article/pii/S0040403925001212

The Engle lab is pleased to welcome Phornphan Yongpanich, who is joining us for one year as a visiting Ph.D. student from Chulabhorn Graduate Institute (CGI) in Bangkok, Thailand. At CGI, Phornphan works in the lab of Prof. Jumreang Tummatorn developing enabling synthetic methods to access pharmaceutically relevant motifs. In the Engle lab, she will delve into the field of organometallic catalysis, while exploring all that San Diego has to offer. Welcome, Phornphan!

We are excited to welcome Alejandro Suárez Lustres, a doctoral student from University of Santiago de Compostela, who joins us for a few months as a visiting student. At his home institution, Alejandro studies palladium catalysis under the mentorship of Profs. Jesús A. Varela Carrete and Carlos Saá, and in the Engle lab he is eager to explore exciting new directions in base metal catalysis.

In an exciting new collaboration with the Baran lab, we find that the combination of alkylsulfonyl hydrazides and nickel catalysis unlocks unprecedented breadth in C(sp²)–C(sp³) cross-coupling via (hetero)aryl C–H activation. The method enables rapid synthesis of valuable attached ring motifs from minimally functionalized starting materials. Through a combination of experimental and computational techniques, we pinned down a unique C–H activation mechanism, termed amine-assisted asynchronous metalation/deprotonation, where the amine base used for radical generation plays a second role in mediating C–H cleavage. Congrats to the team led by Shuanghu and David from the Baran lab and Yilin from our group!

For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/67e0130e6dde43c908ed25da

In the lab’s newest pre-print, we teamed up with the lab of Prof. Peng Liu at the University of Pittsburgh, to break ground on a new research direction aimed at unlocking copper as a general catalyst for nucleometalation to π-bonds. We discovered that under the right circumstances copper(II) is a potent π-Lewis acid that enables addition of various acidic OH and NH nucleophiles to unactivated alkynes, enabling stereodivergent access to enol esters, enolts, and enamides. Congrats to the project team: Juntao, Letian, and Shenghua from Scripps; and Thomas and Mithun from the University of Pittsburgh.

For a link to the pre-print on ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/67a98e806dde43c9083f094e