ORGANOMETALLICS (CHEM 530) 2025


Syllabus
Full playlist of lectures on YouTube

DAY 1: Strong Inference & Main Group Organometallics
Worksheet • Lecture VideoHandout
DAY 2: Coordination Chemistry: History & Electron Counting
Worksheet • Lecture VideoHandout
DAY 3: Coordination Chemistry: Periodic Trends, Structure, & Bonding
Worksheet • Lecture VideoHandout 1Handout 2
DAY 4: Elementary Reactions I
Worksheet • Lecture Video
DAY 5: Elementary Reactions II
Worksheet • Lecture Video
DAY 6: Elementary Reactions III
Worksheet • Lecture Video
DAY 7: GUEST – Ligands Isoelectronic to CO (J. Figueroa, UCSD)
DAY 8: Carbenes and Other M–C and M–X Multiple Bonds I
Worksheet • Lecture Video
DAY 9: Carbenes and Other M–C and M–X Multiple Bonds II
Lecture Video
DAY 10: Principles of Catalysis and Ancillary Ligand Design
Worksheet • Lecture Video
DAY 11: Catalytic Hydrogenation
Worksheet • Lecture Video
DAY 12: MIDTERM
DAY 13: Catalytic Carbonylation
Worksheet • Lecture Video
DAY 14: Wacker- and Heck-Type Alkene Additions
Worksheet • Lecture Video • Handout
DAY 15: Allylic Substitution
Worksheet • Lecture Video • Handout
DAY 16: GUEST – Organometallic Chemistry of (Het)arynes (C. Roberts, UMN)
Lecture Video
DAY 17: GUEST – Application, Mechanism, and Catalyst Activation in the Real World (S. Wisniewski, BMS)
DAY 18: GUEST – Decarboxylative Allylic Substitution (R. Navarro, Occidental College)
DAY 19: GUEST – Catalytic Cross-Coupling (A. Ravn, Scripps Research)
• Worksheet • Lecture Video • Handout
DAY 20: GUEST – Organometallic Innovations in the Pharmaceutical Industry (D. Le, L. Chen, & Z. Chen, Merck)
DAY 21: PROJECT – Wikipedia Page Presentations
DAY 22: Olefin Metathesis
WorksheetLecture Video • Handout 1 • Handout 2

2025 Problem Sets, Midterm, and Final (Grading Keys Available Upon Request)
• Problem Set 1
Midterm
Problem Set 2
Final


Wikipedia Project
Since 2017, the Scripps Organometallics class created >50 new Wikipedia pages on topics relevant to coordination chemistry, organometallics, and catalysis. Below are representative articles voted among the best by the class for each year:

2025
Halogen Dance Rearrangement
Kazuhiko Takai
Metal–Hydride Hydrogen Atom Transfer
Takai–Oshima–Lombardo Methylenation
Transition Metal Vinylidene Complex

2023
• Kharasch—Sosnovsky Reaction
• Metallophotoredox
• Oxidative Phenol Coupling
• Organogermanium Chemistry
• Texaphyrin

2021
• Concerted Metalation Deprotonation
• Crystal Sponge
• Conia-Ene Reaction
• Organotechnicium Compound
• Metal–Ligand Cooperativity
• Shuttle Catalysis

2019
• Artificial Metalloenzymes
• Cross Electrophile Coupling
• Philippe Barbier
• Metallo-Ene Reaction
• Beta-Carbon Elimination

2017
• Activation of Cyclopropanes by Transition Metals
• Mukaiyama Hydration
• Spin Forbidden Reactions
• Tsuji–Wilkinson Decarbonylation Reaction
• Ugi’s Amine