In an exciting new collaboration with the Baran lab, we find that the combination of alkylsulfonyl hydrazides and nickel catalysis unlocks unprecedented breadth in C(sp²)–C(sp³) cross-coupling via (hetero)aryl C–H activation. The method enables rapid synthesis of valuable attached ring motifs from minimally functionalized starting materials. Through a combination of experimental and computational techniques, we pinned down a unique C–H activation mechanism, termed amine-assisted asynchronous metalation/deprotonation, where the amine base used for radical generation plays a second role in mediating C–H cleavage. Congrats to the team led by Shuanghu and David from the Baran lab and Yilin from our group!

For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/67e0130e6dde43c908ed25da

In the lab’s newest pre-print, we teamed up with the lab of Prof. Peng Liu at the University of Pittsburgh, to break ground on a new research direction aimed at unlocking copper as a general catalyst for nucleometalation to π-bonds. We discovered that under the right circumstances copper(II) is a potent π-Lewis acid that enables addition of various acidic OH and NH nucleophiles to unactivated alkynes, enabling stereodivergent access to enol esters, enolts, and enamides. Congrats to the project team: Juntao, Letian, and Shenghua from Scripps; and Thomas and Mithun from the University of Pittsburgh.

For a link to the pre-print on ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/67a98e806dde43c9083f094e

This week we are excited to welcome the newest member of the team, Dr. Masahiro Masuda, who joins Scripps Research from Shionogi & Co, Ltd., where he currently works as a medicinal chemist. Dr. Masuda previously earned his Ph.D. in the Department of Applied Biological Chemistry at the University of Tokyo, working in the area of natural products total synthesis with Prof. Hirosato Takikawa. Welcome to the team, Dr. Masuda!

We bid farewell to Letian Xu who completed his half-year undergrad internship with us this week and is now headed back to Nankai University to write his senior thesis. Letian was a stellar contributor to two different research projects, working under the mentorship of G4 student Juntao Sun. We will miss you and your passion for Bayern Munich, Letian! Can’t wait to see what you accomplish in graduate school and beyond.

Appearing this week in ACS Catalysis, we report a method to access unique enantioenriched products containing a chiral C–N axis via C(Heteroaryl)–H activation. The reaction relies on the dual catalytic action of palladium(II) and an amino acid, the latter of which acts as chiral transient directing group (cTDG). Through a combination of density functional theory calculations, organometallic studies, and H/D exchange experiments, we showed that the role of the cTDG is to preferentially stabilize one of the two possible regioisomeric organopalladium species formed via C–H activation. Numerous classes of heterocycles are tolerated, and the synthetic utility of the products is demonstrated through various derivatizations, including a diastereoselective [4+2] cycloaddition. Congrats to Juntao, Yiyao, Wenji, Chen-Xi, Shenghua, and Quynh!

For a link to the paper in ACS Catalysis, click here: https://pubs.acs.org/doi/10.1021/acscatal.4c06788

As a reminder, an earlier version of this paper was published as a pre-print in ChemRxiv in November 2023: https://chemrxiv.org/engage/chemrxiv/article-details/6541721bc573f893f1889f75

The final peer-reviewed version of our collaborative study with the Payard and Jazzar labs on the synthesis, characterization, and catalytic properties of a novel CAAC-ligated CuH cluster appears this week in Angewandte Chemie. The synthesis of this unique air-stable cluster is enabled by the templating effect of multi-center-2-electron bonds. Akin to Stryker’s reagent, this CuH cluster can mediate conjugate reductions and other useful reactions in organic synthesis. Congrats to the entire team!

For a link to the publication in Angew. Chem. Int. Ed., click here: https://onlinelibrary.wiley.com/doi/10.1002/anie.202419537

As a reminder, an earlier version of this paper was published as a pre-print in ChemRxiv in August 2024: https://chemrxiv.org/engage/chemrxiv/article-details/66c3a7fd20ac769e5f193252

Pd(COD)(DQ), the stable monometallic Pd(0) precatalyst developed by our group in collaboration with Bristol Myers Squibb has been commercialized by MilliporeSigma and can now be conveniently ordered on a variety of scales (#938718). Try Pd(COD)(DQ) in cross-couplings or other reactions where you would normally turn to Pd₂(dba)₃. Combine with a phosphine or NHC ligand of choice in situ, add reactants, and you’ll be off to the races.

For a link to the pre-print describing Pd(COD)(DQ), click here: https://chemrxiv.org/engage/chemrxiv/article-details/65e8f798e9ebbb4db918a09f

For a link to the ordering page on MilliporeSigma, click here: https://www.sigmaaldrich.com/US/en/product/aldrich/938718?srsltid=AfmBOooU1-xETxrRkgPu0QwZueJ4SDwMfSpFj_sH6KmVRm_GNa0n4F9F

The peer-reviewed version of our paper on palladium–bisphosphine mono-oxide (BPMO) complexes is out this week in J. Am. Chem. Soc. Working in close collaboration with the Blackmond lab and Bristol Myers Squibb over the past three years, we developed a robust method for synthesizing numerous structurally diverse palladium–BPMO oxidative addition complexes bearing different ligands, demonstrate a workflow for diagnosing the relevance of BPMO formation to catalytic reactions of interest, and compare solid state structure of oxidized and non-oxidized “matched pair” complexes to determine the structural consequences of BPMO formation. Congrats to the entire team led by Shenghua!

For a link to the full article in J. Am. Chem. Soc., click here: https://pubs.acs.org/doi/10.1021/jacs.4c10718

As a reminder, the an earlier version of this paper was published as a pre-print in ChemRxiv in August 2024: https://chemrxiv.org/engage/chemrxiv/article-details/66aeabbd5101a2ffa809a6fa

The Engle lab gathered over tacos, deserts, and other potluck fixings for our annual white elephant gift exchange. Dramatic gift stealing was down compared to previous years, but spirits were high! The group enjoyed celebrating successful 2024 and looking forward to fantastic year ahead.

In the lab’s latest pre-print, we develop a new and improved catalyst system for “regioreversed” conjugate additions—hydrofunctionalizations that proceed with high levels of α-selectivity owing to the unique mechanism involving a trans-Pd^II(Ar)(H) intermediate. Key to the success of this study was the discovery that trans-spanning bisphosphine ligands can suppress various undesired side reactions and improve reactivity and selectivity with more challenging alkenyl and alkynyl bromide coupling partners. The method employs our lab’s bench-stable pre-catalysts Pd(COD)(DQ) and operates under air without any special precautions. Congrats to the entire team, Wen-Ji, Evan, Sara, Alena, Gabby, and John!

For a link to the ChemRxiv pre-print, click here: https://chemrxiv.org/engage/chemrxiv/article-details/674696ccf9980725cf181fed