The final peer-reviewed version of our collaborative study with the Payard and Jazzar labs on the synthesis, characterization, and catalytic properties of a novel CAAC-ligated CuH cluster appears this week in Angewandte Chemie. The synthesis of this unique air-stable cluster is enabled by the templating effect of multi-center-2-electron bonds. Akin to Stryker’s reagent, this CuH cluster can mediate conjugate reductions and other useful reactions in organic synthesis. Congrats to the entire team!

For a link to the publication in Angew. Chem. Int. Ed., click here: https://onlinelibrary.wiley.com/doi/10.1002/anie.202419537

As a reminder, an earlier version of this paper was published as a pre-print in ChemRxiv in August 2024: https://chemrxiv.org/engage/chemrxiv/article-details/66c3a7fd20ac769e5f193252

Pd(COD)(DQ), the stable monometallic Pd(0) precatalyst developed by our group in collaboration with Bristol Myers Squibb has been commercialized by MilliporeSigma and can now be conveniently ordered on a variety of scales (#938718). Try Pd(COD)(DQ) in cross-couplings or other reactions where you would normally turn to Pd₂(dba)₃. Combine with a phosphine or NHC ligand of choice in situ, add reactants, and you’ll be off to the races.

For a link to the pre-print describing Pd(COD)(DQ), click here: https://chemrxiv.org/engage/chemrxiv/article-details/65e8f798e9ebbb4db918a09f

For a link to the ordering page on MilliporeSigma, click here: https://www.sigmaaldrich.com/US/en/product/aldrich/938718?srsltid=AfmBOooU1-xETxrRkgPu0QwZueJ4SDwMfSpFj_sH6KmVRm_GNa0n4F9F