Enantioselective Ni-Catalyzed Dicarbofunctionalization – Now in Press at JACS

Today’s second paper from the group appears in the Journal of the American Chemical Society and describes the first enantioselective nickel-catalyzed 1,2-dicarbofunctionalization of unactivated alkenes involving a closed-shell pathway. Key to the success of the transformation is the combined use of a sterically bulky monodentate sulfonamide directing group and a chiral hemi-labile bioxazoline (Bn-biOx) ligand, which work together during enantiodetermining arylnickel migratory insertion. This was a massive undertaking that spanned three years and involved collaborators from Scripps (Omar, Taeho, Pranali, Camille, Joe, Brittany, Quynh, Emily, and Jason), University of Pittsburgh (Turki), and Bristol Myers Squibb (Steve). Congrats to everyone on a great team effort!

Click here for a link to the paper in J. Am. Chem. Soc.: https://pubs.acs.org/doi/10.1021/jacs.2c06636

As a reminder, an initial pre-print describing this work first appeared in ChemRxiv back in June: https://chemrxiv.org/engage/chemrxiv/article-details/62b40edc0bbbc1d407726e34