The latest work from Team Nickel and the Bristol Myers Squibb collaboration is now online as a pre-print in ChemRxiv. The paper describes extension of carbonyl-directed nickel-catalyzed alkene 1,2-diarylation to alkenyl ketone substrates, which are challenging owing to the weaker Lewis basicity of the ketone lone pair as well as the increased susceptibility to unwanted isomerization. We also conducted a comparative study of the different reaction conditions that have been published for this family of transformations in order to identify key similarities and differences. Hats off the fantastic team led by visiting student Roman (now a Ph.D. student with Frank Glorius at WWU Münster) and second-year grad student Omar. Also contributing were Joe, Malkanthi, Zi-Qi, and Van, as well as Steve from BMS Process. Awesome stuff, team!
For a link to the pre-print, click here: https://chemrxiv.org/articles/preprint/Nickel-Catalyzed_1_2-Diarylation_of_Alkenyl_Ketones_A_Comparative_Study_of_Carbonyl-Directed_Reaction_Systems/14150174