Alpha-Hydroarylation Paper Accepted in J. Am. Chem. Soc.

Our collaborative paper with Bristol-Myers Squibb on α-selective hydroarylation of acrylates and acrylamides has been accepted for publication in J. Am. Chem. Soc. Detailed mechanistic studies revealed that the reaction proceeds via a [Pd(Ar)(H)] intermediate, which undergoes migratory insertion to deliver the hydride group to the β-position, generating a [Pd(Ar)(enolate)]; C–C reductive elimination then furnishes the final product. The reaction is notable for its operational simplicity, mild reaction conditions, and widely available starting materials. Congrats to Engle lab authors Alena and John (now at BMS Process), as well as BMS collaborators Candice (Process Chemistry) and Emily (Discovery Chemistry) As a reminder, this manuscript first appeared as a ChemRxiv pre-print (click here).

For a link to the paper, click here: https://pubs.acs.org/doi/10.1021/jacs.0c03040