Practical 1,2-Diarylation of Alkenes Directed by Simple Amides – Now In Press

The nickel team strikes again, with a final version of our nickel-catalyzed alkene 1,2-diarylation paper appearing online in final form at J. Am. Chem. Soc. (click here). Through identification of an effective electron-deficient olefin ligand, this catalytic system allow for use of simple commonly encountered primary, secondary, and tertiary amides as directing groups, including those that are native to various target compounds of interest. Additionally, this work represents one of the rare cases in 1,2-diarylation chemistry where an aryl boronic acid derivative can be used as the nucleophilic coupling partner. Congratulations to Joe, Roman, Van, and Malkanthi from the Engle lab and Steve and Martin from Bristol-Myers Squibb. Thanks to everyone involved for a great collaboration. In case anyone missed it, a pre-print of this work was published on ChemRxiv back in early November (click here).