In our latest work, we describe a dual catalytic double Mizoroki–Heck arylation of ortho-(2-propenyl)benzaldehydes to furnish a special class of styrenyl products exhibiting equivalent atrop- and positional isomerism. The molecules are unique; inversion about the hindered C(aryl)–C(alkenyl) bond is equivalent to relocating the olefin to adjacent position (i.e., transposing a single H atom). Congrats to the entire collaborative team: Amit, Yiyao, Wen-Ji, and Madeline from Scripps Research; and Turki from the Liu lab at the University of Pittsburgh.

For a link to the pre-print in ChemRxiv, click here: https://chemrxiv.org/engage/chemrxiv/article-details/6835b62d1a8f9bdab53f41a4