The final peer-reviewed version of our tungsten-catalyzed olefin isomerization method appears in press this week in Chemical Science. The method offers a mild and reliable way to perform kinetic isomerization of β,γ-unsaturated carbonyl compounds without competitive formation of the thermodynamic (conjugated) byproduct. We find that E versus Z stereoselectivity can be controlled by modulating the ligand environment around the tungsten center to grant access to either isomer as desired. Congrats to the project team, Tanner, Camille, Hang Chi (Calvin), and Raul!

For a link to the paper in Chemical Science, click here: https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc07093c

As a reminder, an earlier version of this paper was published as a pre-print in ChemRxiv in November 2023: https://chemrxiv.org/engage/chemrxiv/article-details/6554cf6adbd7c8b54b514d16