In the lab’s latest pre-print, we develop a new and improved catalyst system for “regioreversed” conjugate additions—hydrofunctionalizations that proceed with high levels of α-selectivity owing to the unique mechanism involving a trans-PdII(Ar)(H) intermediate. Key to the success of this study was the discovery that trans-spanning bisphosphine ligands can suppress various undesired side reactions and improve reactivity and selectivity with more challenging alkenyl and alkynyl bromide coupling partners. The method employs our lab’s bench-stable pre-catalysts Pd(COD)(DQ) and operates under air without any special precautions. Congrats to the entire team, Wen-Ji, Evan, Sara, Alena, Gabby, and John!
For a link to the ChemRxiv pre-print, click here: https://chemrxiv.org/engage/chemrxiv/article-details/674696ccf9980725cf181fed
Molecular Complexity through Catalysis 