Together with the Sharpless, Blackmond, and Liu labs, as well as the teams at Enamine and Pfizer, in a ChemRxiv pre-print this week, we explore a family of intriguing chemicals with largely unannotated reactivity, alkyl sulfonyl fluorides. Under PdII/PdIV catalysis, we unlock the ambiphilic reactivity of alkyl l sulfonyl fluorides with olefins to access unique substituted cyclopropanes.
This was a fun collaboration spanning many years made possible a by a great team, including Yilin Cao, Warabhorn (Por) Rodphon, Turki Alturaifi, Al Vicente Riano Lisboa, Hermione Ren, Job Struijs, Hui-Qi Ni, and several industrial collaborators. Congrats!
For a link to the ChemRxiv pre-print, click here: https://chemrxiv.org/engage/chemrxiv/article-details/672b9b3cf9980725cf547804
Molecular Complexity through Catalysis 